Caralluma Fimbriata Study

Trial begins 2nd week in October 2013 for 10 weeks.

You and your child are invited to participate in a PWS research project  through Victoria University. The purpose of this study is to examine the  effectiveness of Caralluma fimbriata extract (CFE); on appetite and satiation, for a group of individuals with a confirmed diagnosis of PWS. Caralluma is an edible cactus  succulent used for centuries in India as an appetite suppressant. There has been  anecdotal evidence of CFE’s effect on hunger within a single case study of one child  with PWS and testimonials of change from a mother of an adult. There has also been  some evidence of change for some but not all, through our Victoria University Pilot  study. This study will now be a continuation of the Australian pilot trial; including  participants from all over Australia and New Zealand. 

In this 10 week PhD project, we will utilize the design of a double blind, randomized, cross-over trial, with an oral supplementation of the intervention or placebo. (No invasive treatment). This means a group of children/adolescents; ages of 5 - 17yrs , will take either the intervention or placebo as a drink for 4 weeks with breakfast; this is followed by a two week break and then they will ingest the other treatment or placebo again for 4 weeks. Evidence of any change to satiety, hunger or behaviour for the group, will be identified by repeated measures (weekly) through a reliable PWS parent/carer hyperphagia questionnaires. All participants will need GP consent and a reliable measurement of the participant’s weight for dosage. They will need to fit the inclusion criteria and the parent/carers will be contacted by phone and email weekly during their participation.

This project is being conducted by Joanne Griggs (PhD candidate) and supervised by A/Prof Michael Mathai and Dr Xiao Su and through the School of Biomedical and Health Sciences at Victoria University. 

To partake in this research, or if you have any queries,

Please contact: Joanne Griggs, Student Researcher, College of Health and Biomedicine, Victoria University, Ph: 0414800411 email:

Or, Dr Michael Mathai, Principle Researcher, College of Health and Biomedicine, Victoria University, Ph: 03 99192211 email:

Or, Dr Xiao Su, Associate Researcher, College of Health and Biomedicine, Victoria University, Ph: 03-99192318, email:

For more information about this study, please click here.